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[MCE] New Bioactive Molecules for August 2024

[MCE] New Bioactive Molecules for August 2024

MedChemExpress - Master of Bioactive Molecules (Inhibitors. Screening Libraries. Proteins)
MedChemExpress (MCE) provides a wide range of life-science biochemicals, including more than 100,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

CAS No.: 55096-26-9

Nalmefene

Research Area: Opioid Receptor/Neurological Disease

Nalmefene structure
An orally active opioid antagonist, which acts as an antagonist at the μ-opioid (MOR) and δ-opioid receptors (KOR) and a partial agonist at the κ-opioid receptor (KOR).
Used for the research of opioid overdose and alcohol dependence.

Solubility: DMSO: 175 mg/mL (515.57 mM; Need ultrasonic)

CAS No.: 1380359-84-1

PARPi-FL

Research Area: PARP/Fluorescent Dye/Cancer

PARPi-FL structure
A fluorescent potent PARP inhibitor with an IC50 of 12 nM.
Composed of a PARP inhibitor (Olaparib) conjugated to Bodipy FL.
Can be used as an imaging agent to detect glioblastomas in vivo.

Solubility: DMSO: 50 mg/mL (78.07 mM; Need ultrasonic)

CAS No.: 2444297-08-7

Boserolimab

Research Area: TNF Receptor/CD27/Lung Cancer

Boserolimab structure
Anti-human CD27 agonist humanized IgG1 antibody for cancer immunotherapy.
Binds to CD27 to provide a costimulatory signal that enhances T-cell-mediated responses.
Used for the research of lung cancer.

Solubility: Solution: 11.57 mg/mL

MCE Metabolism Analysis Kits
Cell metabolism refers to the total of a series of orderly chemical reactions occurring within cells to maintain life. Cell metabolism is typically divided into two categories: anabolic metabolism (or anabolism) and catabolic metabolism (or catabolism).
MCE offers a range of high-quality metabolism assay kits to support your scientific research endeavors.
Cat. No. Product Name Application
HY-K0311 GSH/GSSG Assay Kit Detection of reduced and oxidized glutathione (GSH/GSSG) levels
HY-K1501 NADP+/NADPH Assay Kit (WST-8) Detection of NADP+ and NADPH levels
HY-K0313 NAD+/NADH Assay Kit (WST-8) Detection of NAD+ and NADH levels
HY-K0314 ATP Assay Kit Detection of ATP levels
HY-K0315 Hematoxylin-Eosin Staining Kit Cell staining
MCE Natural Products
Lipids are a class of water-insoluble biomolecules, including compounds such as fatty acids, glycerol, and phospholipids. They play a crucial role in maintaining the health and normal functioning of living organisms.
Product Name Description
N-Palmitoyl-D-sphingomyelin Can be used for the synthesis of lipid nanoparticles.
L-Palmitoylcarnitine chloride Inhibits KATP channel activity through interaction with Kir6.2.
Palmitoylglycine An endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.
2-Oleoylglycerol A GPR119 agonist that stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo.
Monogalactosyldiacylglycerol Facilitates the diffusion process of electron transfer in photosynthesis and may be used in the packaging of natural proteins.
MCE Isotope-labeled Compounds
Latest Publications Citing Use of MCE Products
Covers of Recent Publications Nature.
2024 Jul;631(8020):415-423.
Nature.
2024 Jun;630(8018):968-975.
Science.
2024 Jun 7;384(6700):eadk0775.
Cell Signaling Pathway

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