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Use LFS to determine more complex structures


Achieve higher success rates with the new Ligand-Friendly Screen, optimised for compound binding studies.

 

Resulting in 190 structures over 10 years of crystallisation trials, the Ligand-Friendly Screen (LFS)1 is the single most successful of the 11 sparse-matrix screens used with in initial trials for new projects at the Structural Genomics Consortium (SGC) in Oxford. The LFS is based on the popular PACT screen from Prof. Newman2 of Collaborative Crystallisation Centre, CSIRO, Australia and explores combinations of PEG (1K to 6K), salts and buffers at near-physiological pH in a semi-systematic manner.

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