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New Small Molecules from MCE for November 2020

New Small Molecules from MCE for November 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
• Estrogen Receptor/ERR Antagonist
Giredestrant             CAS No. : 1953133-47-5

Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity.

Compound Screening Libraries



50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• TGF-beta/Smad Inhibitor
Disitertide TFA

Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer.

Cell Signaling Pathway

• PKC Inhibitor
Delcasertib hydrochloride                                      CAS No. : 143797-62-0

Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).

• Recent Publication Citing used MCE

Nature. 2020 Oct;586(7829):407-411. (IF: 42.778).

• Phosphodiesterase (PDE) Inhibitor

BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.

• PI3K Inhibitor
MSC2360844                                     CAS No. : 1305267-37-1

MSC2360844 is a potent, orally active and selective PI3Kδ inhibitor, with an IC50 of 145 nM. MSC2360844 shows highly selective against a panel of 278 additional kinases.


Other New Products This Month

ML406 (Bacterial) SB 243213 (5-HT Receptor) Plecanatide (Guanylate Cyclase)
Diloxanide (Parasite) VAF347 (Aryl Hydrocarbon Receptor) GSK046 (Epigenetic Reader Domain)
KL001 (Cryptochrome) Ganaplacide hydrochloride (Parasite) GSK356278 (Phosphodiesterase (PDE))
Jatrorrhizine (Alkaloids) …