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128381 Singapore.

 

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New Small Molecules from MCE for October 2020

New Small Molecules from MCE for October 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

 

• Bacterial Inhibitor
SPR206 acetate                                 CAS No. : 2408422-41-1

SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L.

Compound Screening Libraries

 

 

50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• Parasite Inhibitor
Purfalcamine                                 CAS No. : 1038620-68-6

Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage.

Cell Signaling Pathway

• PARP Inhibitor
RBN012759                                      CAS No. : 2360851-29-0

RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.

• Recent Publication Citing used MCE

1. Nature. 2020 Sep;585(7824):293-297.
2. Cancer Discov. 2020 Sep;10(9):1282-1295.
3. Cell Stem Cell. 2020 Sep 12;S1934-5909(20)30399-4. doi:
10. 1016/j.stem.2020.08.003.

• CXCR Agonist
PS372424 hydrochloride                            CAS No. : 1596362-29-6

PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.

• Epigenetic Reader Domain Inhibitor
NEO2734                                     CAS No. : 2081072-29-7

NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.

 

Other New Products This Month

MCP110 (Ras) AG-494 (EGFR) SAG dihydrochloride (Smo)
VU-29 (mGluR) SR-717 (STING) Ilaprazole sodium (Proton Pump)
Mepazine (MALT1) PU02 (5-HT Receptor) SKF-83566 (Dopamine Receptor)
Avatrombopag (Integrin) …