13 Oct New Small Molecules from MCE for October 2020
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.
|• Bacterial Inhibitor
SPR206 acetate CAS No. : 2408422-41-1
SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L.
Compound Screening Libraries
50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.
|• Parasite Inhibitor
Purfalcamine CAS No. : 1038620-68-6
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage.
Cell Signaling Pathway
|• PARP Inhibitor
RBN012759 CAS No. : 2360851-29-0
RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.
|• Recent Publication Citing used MCE
1. Nature. 2020 Sep;585(7824):293-297.
|• CXCR Agonist
PS372424 hydrochloride CAS No. : 1596362-29-6
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation.
|• Epigenetic Reader Domain Inhibitor
NEO2734 CAS No. : 2081072-29-7
NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.
Other New Products This Month
|MCP110 (Ras)||AG-494 (EGFR)||SAG dihydrochloride (Smo)|
|VU-29 (mGluR)||SR-717 (STING)||Ilaprazole sodium (Proton Pump)|
|Mepazine (MALT1)||PU02 (5-HT Receptor)||SKF-83566 (Dopamine Receptor)|
|Avatrombopag (Integrin) …|
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