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New Small Molecules from MCE for September 2020

New Small Molecules from MCE for September 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, recombinant proteins, dye reagents, peptides and natural compounds for laboratory and scientific use.

• Over 25,000 bioactive molecules in stock
• Target 375 key proteins in 20+ signaling pathways
• Quality reports (LC/MS, NMR and HPLC) for each product
• Release more than 500 of the newest biochemicals per month
• High purity & competitive prices
• Data sheet with detailed biological information
• Delivery within 24 hours
• Complement System
AMY-101 acetate

AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.

Compound Screening Libraries



50 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• AMPK Activator
IM156                                                     CAS No. : 1422365-94-3

IM156 (HL156A; HL271 acetate), a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.

Cell Signaling Pathway

• CDK Inhibitor
K00546                                       CAS No. : 443798-47-8

K00546 is a potent CDK1 and CDK2 inhibitor with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. K00546 is also a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50s of 8.9 nM and 29.2 nM, respectively.

• Recent Publication Citing used MCE

1. Cell. 2020 Aug 6;182(3):545-562.e23.
2. Cancer Cell. 2020 Jul 30;S1535-6108(20)30369-X. doi:10.1016/j.ccell.2020.07.008.
3. Cell Metab. 2020 Aug 4;32(2):287-300.e7.
4. Cell Stem Cell. 2020 Jul 14;S1934-5909(20)30288-5. doi:10.1016/j.stem.2020.06.021.

• Microtubule/Tubulin Inhibitor
Batabulin sodium

Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death.

• iGluR Antagonist
TCN 201                                      CAS No. : 852918-02-6

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3).


Other New Products This Month

Infliximab (TNF Receptor) Phenidone (COX) Pramipexole (Dopamine Receptor)
Ropivacaine (Sodium Channel) Loxoprofen (COX) CRT0044876 (DNA/RNA Synthesis)
GI-530159 (Potassium Channel) Ganciclovir (CMV) Win 18446 (Aldehyde Dehydrogenase (ALDH))
Gemigliptin (Dipeptidyl Peptidase) …