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New Small Molecules from MCE for June 2020

New Small Molecules from MCE for June 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 25,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• CCR Antagonist
PF-04634817                  CAS No. : 1228111-63-4

PF-0463481 is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy.

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• Glycolysis Related Compound
DC-5163                                   CAS No. : 897771-47-0

DC-5163 is a potent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor with an IC50 of 176.3 nM and a Kd of 3.192 μM. DC-5163 can inhibit glycolysis pathway partially. DC-5163 also selectively inhibits cancer cell proliferation and induces apoptosis.

Cell Signaling Pathway

• TAM Receptor Inhibitor
ONO-7475                          CAS No. : 1646839-59-9

ONO-7475 is a potent, selective, and orally active novel Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

• Recent Publication Citing used MCE

1. Nature. 2020 Apr;580(7803):386-390.
2. Nature. 2020 Mar;579(7799):433-437.
3. Science. 2020 Feb 14;367(6479):806-810.
4. Cell. 2020 Mar 5;180(5):941-955.e20.

• TOPK Inhibitor
OTS514               CAS No. : 1338540-63-8

OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.

• ULK Activator
LYN-1604          CAS No. : 2310109-38-5

LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).


Other New Products This Month

ML346 (HSP) Taurolidine (Bacterial) Bepotastine (Histamine Receptor)
Xevinapant (IAP) Chloroquine (Parasite) Emedastine (Histamine Receptor)
A-205804 (Integrin) Fesoterodine fumarate (mAChR) Ulipristal (Progesterone Receptor)
SD-169 (p38 MAPK) …