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New Small Molecules from MCE for April 2020

New Small Molecules from MCE for April 2020

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 15,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use. If you need these products, please do not hesitate to contact us via


• Proteasome Inhibitor
Marizomib                    CAS No. : 437742-34-2Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively).

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• FABP Inhibitor
SBFI-26               CAS No. : 1541207-06-0SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects.

Cell Signaling Pathway

• Epigenetic Reader Domain Inhibitor
MS31 MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 is not toxic to nontumorigenic cells.
• 5-LOX/COX Inhibitor
FPL 62064         CAS No. : 1005775-56-3FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity.
• MRTF Inhibitor
CCG-222740                     CAS No. : 1922098-69-8CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.


Other New Products This Month

EC5026 (sHE) Afoxolaner (GABA Receptor) OG-L002 (Histone Demethylase)
MRTX849 (Ras) Perospirone (5-HT Receptor) Dihydrexidine (Dopamine Receptor)
TCID (Deubiquitinase) V-9302 hydrochloride (ASCT2) FGTI-2734 mesylate (Farnesyl Transferase)
SR-31747 (Sigma Receptor) …