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New Small Molecules from MCE for October 2019

New Small Molecules from MCE for October 2019

MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 15,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.

• PI4K Inhibitor
KDU731                                     CAS No.: 1610610-48-4KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.

Compound Screening Libraries



32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.

• NEDD8-activating Enzyme Inhibitor
SZM223 hydrochloride                        CAS No. : 332348-12-6ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.

Cell Signaling Pathway

• LRRK2 Inhibitor
PFE-360                                                  CAS No.: 1527475-61-1

MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM.

• Toll-like Receptor(TLR) Antagonist
IAXO-102                                              CAS No.: 1115270-63-7

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.

• VEGFR Inhibitor
AG-13958                                               CAS No.: 319460-94-1SNT207858 is a selective, blood brain barrier penetrating, AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD).


Other New Products This Month

Bisindolylmaleimide X (PKC) RU.521 (cGAS) FT113 (Fatty Acid Synthase (FAS))
CP-409092 (GABA Receptor) Qstatin (Bacterial) Furprofen (Prostaglandin Receptor)
Indibulin (Microtubule/Tubulin) Silychristin (Flavonoids) Cridanimod (Progesterone Receptor)
ATM-3507 trihydrochloride (Myosin) …