10 Oct New Small Molecules from MCE for October 2019
MCE (MedChemExpress) provides a wide range of lifescience biochemicals, including more than 15,000 bioactive compounds, dye reagents, peptides and natural compounds for laboratory and scientific use.
|• PI4K Inhibitor
KDU731 CAS No.: 1610610-48-4KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo. KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety.
Compound Screening Libraries
32 specific libraries for high throughput screening (HTS) and high content screening (HCS). Optimized for drug screening and new indication research.
|• NEDD8-activating Enzyme Inhibitor
SZM223 hydrochloride CAS No. : 332348-12-6ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme (NAE) inhibitor with excellent anticancer activity.
Cell Signaling Pathway
|• LRRK2 Inhibitor
PFE-360 CAS No.: 1527475-61-1
MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM.
|• Toll-like Receptor(TLR) Antagonist
IAXO-102 CAS No.: 1115270-63-7
Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
|• VEGFR Inhibitor
AG-13958 CAS No.: 319460-94-1SNT207858 is a selective, blood brain barrier penetrating, AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD).
Other New Products This Month